AFV was given homage in a Rugrats episode called "America's Wackiest Home Movies". Grandpa Lou won the $10,000 even though Drew and Stu got hurt.
YouTuber Nalts parodied AFV as AFB (America's Funniest Bloopers) in one of his videos.
In The Simpsons episode, "A Star is Burns", Homer watches a film by Hans Moleman called "Man Getting Hit By Football". Hans gets hit in the groin and Homer laughs hysterically. He says, "Give that man the $10,000!" The film host replies with, "This isn't America's Funniest Home Videos!", but Homer thinks the ball in the groin was funny and he tells him to roll the clip again. In an episode of CatDog, AFV was parodied as Winslow's Home Videos, where host Winslow showed funny clips of Cat and Dog. Note: This clip can also be seen on the VHS of The Rugrats Movie.
AFV was also seen as a parody on Blue Collar TV. Tom Bergeron did not make an appearance, but someone played Tom. In the Disney Sing Along Songs episode "Pongo and Perdita", AFV was parodied as "Hot Dog: America's Funniest Dog Tricks". Pongo, Perdita, and the puppies were watching on their TV. The song "Do Your Ears Hang Low?" played when the show was going on. Seattle's sketch comedy show Almost Live! parodied the show as "America's Funniest Most Wanted", which featured funny crime videos; John Keister plays a Bob Saget-style host.
In the Dinosaurs episode "Family Challenge", the Sinclairs watch a parody of AFV called Pangaea's Funniest Home Injuries, which was followed by Pangaea's 2nd Funniest Home Injuries. MTV's Pirate TV did a parody called "Central America's Funniest Home Videos". The Disney Channel's The All-New Mickey Mouse Club did a parody called "America's Nuttiest Home Videos". In 1995, the NBC late-night sketch comedy show Saturday Night Live parodied AFV as "America's Funniest Hate Videos"; which featured funny videos that really hate, and was hosted by Bob Saget, featuring an edited version of "The Funny Things You Do".
Caroline's Comedy Hour did a parody called "A&E presents History's Funniest Home Videos". AFV was parodied on South Park as "America's Stupidest Home Videos" in the Season 1 episode "Cartman's Mom is a Dirty Slut". In 1990, Fox's sketch comedy show In Living Color parodied the show as "America's Funniest Security Camera Videos", in which Jim Carrey portrayed Bob Saget. The Annoying Orange episode "Tech Support" featured AFV parodied as America's Best Groin Shots (ABGS), as Orange watches it on his computer. A season 2 episode of Camp Candy starring John Candy paid homage to AFV entitled; "Camp Candy's Funniest Home Videos", which was a clip show episode of funny moments from the show. Histeria did a parody of AFV entitled, "Presidential's Funniest Home Movies", with Loud Kiddington and Miss Information as the hosts. It featured presidential moments in American history that went wrong.